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Harmony Navigator 2 Download The Application

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Database of Single Nucleotide Polymorphisms (dbSNP)Full Name 5-hydroxytryptamine receptor 2B provided by HGNC Primary source HGNC:HGNC:5294 See related Ensembl:ENSG00000135914 MIM:601122 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota Metazoa Chordata Craniata Vertebrata Euteleostomi Mammalia Eutheria Euarchontoglires Primates Haplorrhini Catarrhini Hominidae Homo Also known as 5-HT2B 5-HT-2B 5-HT(2B) Summary This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Database of Genomic Structural Variation (dbVar) Online Mendelian Inheritance in Man (OMIM) Database of Genotypes and Phenotypes (dbGaP)

Expression Biased expression in endometrium (RPKM 10.3), adrenal (RPKM 7.1) and 8 other tissues See more Orthologs mouse all NEW Try the new Gene table Alternatively spliced transcript variants have been found for this gene. However, other factors, such as elevated testosterone levels, may also be involved. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior.

PMID 30347896, Free PMC Article Int J Mol Sci, 2018 Oct 21. Transcription of the Human 5-Hydroxytryptamine Receptor 2B (HTR2B) Gene Is under the Regulatory Influence of the Transcription Factors NFI and RUNX1 in Human Uveal Melanoma.

The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Source sequence(s) AC009407, BC063123, X77307 Consensus CDS CCDS2483.1 UniProtKB/Swiss-Prot P41595 Related ENSP00000258400.3, ENST00000258400.4 Conserved Domains (2) summary pfam00001Location: 71 в†’ 380 7tm_1 7 transmembrane receptor (rhodopsin family) cl21561Location: 72 в†’ 188 7tm_4 Olfactory receptorNM_001320758.2 в†’ NP_001307687.1 5-hydroxytryptamine receptor 2B isoform 2Status: REVIEWED Description Transcript Variant: This variant (2) uses an alternate splice junction in the 5' end compared to variant 1. MRNA and Protein(s)NM_000867.5 в†’ NP_000858.3 5-hydroxytryptamine receptor 2B isoform 1See identical proteins and their annotated locations for NP_000858.3Status: REVIEWED Description Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Identify version mismatches by comparing the version of the RefSeq inThis section to the one reported in Genomic regions,Transcripts, and products above. ExplainThese reference sequences are curated independently of the genomeAnnotation cycle, so their versions may not match the RefSeq versions in the currentGenome build. PMID 29875475, Free PMC ArticleSee citations in PubMed for homologs of this gene provided by HomoloGeneThese reference sequences exist independently of genome builds.

Transcriptomine: regulation of the HTR2B gene by nuclear receptor signaling pathways Nuclear Receptor Signaling Atlas (NURSA) Kyoto Encyclopedia of Genes and Genomes GenScript latest version of gene cDNA ORF Clone BioGRID CRISPR Screen Phenotypes (9 hits/1039 screens) BioGRID Open Repository of CRISPR Screens (ORCS)